Most physicians are familiar with GSH in regards to its role in hepatic function, as a detoxifying substrate for acetaminophen overdoses, and more recently its importance in the maintenance of T-cell competence in HIV. However the clinical application of GSH enhancement is just beginning to be elaborated and will have far-reaching effects.Antioxidation: Glutathione is the major naturally-occurring antioxidant present in our cells. Other antioxidants introduced though our diet such as vitamins C and E depend on GSH for their function and recycling within the cell. The field of free-radical biology is burgeoning and the list of disease states linked to oxidative stress is growing rapidly.
Toxicology: Glutathione is a key substrate for hepatic phase II metabolic pathways, which are taxed daily not only by a variety of prescription and non-prescription drugs, but also by a host of environmental toxins including heavy metals and many byproducts of cigarette smoke and fuel exhaust.
Immune Modulation: Lymphocytes, in particular T-cell subsets have a high demand for adequate GSH for their function and replication. GSH depletion in face of an acute or chronic inflammatory process, aging or infection, will lead to a blunted immune response.
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